MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

Author:

Major-Monfried Hannah1,Renteria Anne S.1,Pawarode Attaphol2,Reddy Pavan2,Ayuk Francis3,Holler Ernst4,Efebera Yvonne A.5,Hogan William J.6,Wölfl Matthias7,Qayed Muna8,Hexner Elizabeth O.9,Wudhikarn Kitsada10,Ordemann Rainer11,Young Rachel1,Shah Jay1,Hartwell Matthew J.1,Chaudhry Mohammed S.1,Aziz Mina1,Etra Aaron1,Yanik Gregory A.2,Kröger Nicolaus3,Weber Daniela4,Chen Yi-Bin12,Nakamura Ryotaro13,Rösler Wolf14,Kitko Carrie L.15,Harris Andrew C.16,Pulsipher Michael17,Reshef Ran18,Kowalyk Steven1,Morales George1,Torres Ivan1,Özbek Umut19,Ferrara James L. M.1,Levine John E.1

Affiliation:

1. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

2. Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI;

3. Department of Stem Cell Transplantation, University Medical Center, Hamburg-Eppendorf, Germany;

4. Blood and Marrow Transplantation Program, University of Regensburg, Regensburg, Germany;

5. Blood and Marrow Transplantation Program, Ohio State University, Columbus, OH;

6. Blood and Marrow Transplantation Program, Mayo Clinic, Rochester, MN;

7. Pediatric Blood and Marrow Transplantation Program, Children’s Hospital, University of Würzburg, Würzburg, Germany;

8. Pediatric Blood and Marrow Transplantation Program, Aflac Cancer and Blood Disorders Center, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA;

9. Blood and Marrow Transplantation Program, University of Pennsylvania, Philadelphia, PA;

10. Blood and Marrow Transplantation Program, Chulalongkorn University, Bangkok, Thailand;

11. Medical Department 1, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;

12. Bone Marrow Transplantation Program, Massachusetts General Hospital, Boston, MA;

13. Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA;

14. Department of Internal Medicine 5, Hematology/Oncology, University Hospital Erlangen-Nuremburg, Erlangen, Germany;

15. Pediatric Blood and Marrow Transplantation Program, Vanderbilt University Medical Center, Nashville, TN;

16. Blood and Marrow Transplantation Program, University of Utah, Salt Lake City, UT;

17. Blood and Marrow Transplantation Program, Children’s Hospital of Los Angeles, Los Angeles, CA;

18. Blood and Marrow Transplantation Program, Columbia University, New York, NY; and

19. Biostatistics Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Abstract

Key Points Biomarker scores generated after 1 week of steroid treatment of GVHD are prognostic. Biomarkers reflect prognosis better than early clinical response to GVHD treatment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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