PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy-Reference-Cited by-同舟云学术

PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy

Published:2017-04-13 Issue:15 Volume:129 Page:2186-2197
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Asano Takeru¹,Meguri Yusuke¹,Yoshioka Takanori¹,Kishi Yuriko¹,Iwamoto Miki¹,Nakamura Makoto¹,Sando Yasuhisa¹,Yagita Hideo²,Koreth John³,Kim Haesook T.⁴^ORCID,Alyea Edwin P.³,Armand Philippe³,Cutler Corey S.³,Ho Vincent T.³,Antin Joseph H.³,Soiffer Robert J.³,Maeda Yoshinobu¹,Tanimoto Mitsune¹,Ritz Jerome³,Matsuoka Ken-ichi¹³

Affiliation:

1. Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

2. Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan;

3. Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and

4. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA

Abstract

Key Points IL-2 induces expression of PD-1 on Tregs, and PD-1 blockade promotes Treg differentiation and apoptosis. PD-1 regulates IL-2–induced Treg proliferation and prolongs Treg survival in murine models and in patients receiving low-dose IL-2 therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/15/2186/1400571/blood741629.pdf

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