Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Published:2017-06-15 Issue:24 Volume:129 Page:3221-3226
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rahman Sunniyat¹,Magnussen Michael¹,León Theresa E.¹,Farah Nadine¹,Li Zhaodong²,Abraham Brian J.³,Alapi Krisztina Z.¹,Mitchell Rachel J.¹,Naughton Tom¹,Fielding Adele K.¹,Pizzey Arnold¹,Bustraan Sophia¹,Allen Christopher¹,Popa Teodora¹,Pike-Overzet Karin⁴,Garcia-Perez Laura⁴,Gale Rosemary E.¹,Linch David C.¹,Staal Frank J. T.⁴,Young Richard A.³⁵,Look A. Thomas²⁶,Mansour Marc R.¹

Affiliation:

1. Department of Haematology, University College London Cancer Institute, London, United Kingdom;

2. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

3. Whitehead Institute for Biomedical Research, Cambridge, MA;

4. Department of Immunohematology, Leiden University Medical Center, Leiden, The Netherlands;

5. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA; and

6. Division of Hematology/Oncology, Children’s Hospital, Boston, MA

Abstract

Key Points Recurrent intronic mutations that create probable MYB, ETS1, and RUNX1 binding sites occur at the LMO2 promoter in some T-ALL patients. CRISPR/Cas9-mediated disruption of the mutant MYB site in PF-382 cells markedly downregulates LMO2 expression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/24/3221/1401532/blood742148.pdf

Reference27 articles.

1. LMO2 at 25 years: a paradigm of chromosomal translocation proteins;Chambers;Open Biol,2015

2. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13;Boehm;Proc Natl Acad Sci USA,1991

3. T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes;Fisch;Oncogene,1992

4. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression;Herblot;Nat Immunol,2000

5. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling;Dik;J Exp Med,2005

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