Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents-Reference-Cited by-同舟云学术

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents

Published:2017-03-30 Issue:13 Volume:129 Page:1823-1830
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Asshoff Malte¹,Petzer Verena¹,Warr Matthew R.²,Haschka David¹,Tymoszuk Piotr¹,Demetz Egon¹,Seifert Markus¹,Posch Wilfried³,Nairz Manfred¹,Maciejewski Pat²,Fowles Peter²,Burns Christopher J.²⁴,Smith Gregg²,Wagner Kay-Uwe⁵,Weiss Guenter¹,Whitney J. Andrew²,Theurl Igor¹

Affiliation:

1. Department of Internal Medicine VI (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria;

2. Department of Biology, Gilead Sciences, Inc., Foster City, CA;

3. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria;

4. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; and

5. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE

Abstract

Key Points MMB ameliorates anemia in a rodent anemia of chronic disease model by inhibiting activin receptor-like kinase-2 activity. Hepcidin-dependent ferroportin degradation is independent of JAK2 phosphorylation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/13/1823/1399149/blood740092.pdf

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4. Hepcidin, a urinary antimicrobial peptide synthesized in the liver;Park;J Biol Chem,2001

5. Two to tango: regulation of Mammalian iron metabolism;Hentze;Cell,2010

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