Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment-Reference-Cited by-同舟云学术

Donor hematopoiesis in mice following total lymphoid irradiation requires host T-regulatory cells for durable engraftment

Published:2014-05-01 Issue:18 Volume:123 Page:2882-2892
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Müller Antonia M. S.¹²³,Poyser Jessica¹,Küpper Natascha J.¹,Burnett Cassandra¹,Ko Rose M.¹,Kohrt Holbrook E.K.⁴,Florek Mareike¹,Zhang Pei¹,Negrin Robert S.¹,Shizuru Judith A.¹

Affiliation:

1. Stanford University School of Medicine, Department of Medicine, Division of Blood and Marrow Transplantation, Stanford, CA;

2. University Hospital Zurich, Division of Hematology, Zurich, Switzerland;

3. University Medical Center Freiburg, Department of Hematology, Oncology and Stem-Cell Transplantation, Freiburg, Germany; and

4. Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA

Abstract

Key Points After TLI, donor blood stem cells first engraft in irradiated marrow and gradually redistribute into unexposed sites. Long-term donor cell engraftment requires the presence of regulatory host cells that promote host stem-cell cycling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/18/2882/1376843/2882.pdf

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