Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis-Reference-Cited by-同舟云学术

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis

Published:2015-09-03 Issue:10 Volume:126 Page:1224-1233
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ouseph Madhu M.¹,Huang Yunjie¹,Banerjee Meenakshi¹,Joshi Smita¹,MacDonald Laura²,Zhong Yu¹,Liu Huijuan¹,Li Xianting³⁴,Xiang Binggang⁵,Zhang Guoying⁵,Komatsu Masaaki⁶⁷,Yue Zhenyu³⁴,Li Zhenyu⁵,Storrie Brian²,Whiteheart Sidney W.¹,Wang Qing Jun¹

Affiliation:

1. Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY;

2. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR;

3. Department of Neurology and

4. Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

5. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY;

6. Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; and

7. Department of Biochemistry, School of Medicine, Niigata University, Niigata, Japan

Abstract

Key Points Autophagy, an essential degradation pathway, is constitutively active in resting platelets and is induced upon platelet activation. Platelet autophagy is indispensable for hemostasis and thrombus formation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/10/1224/1388749/1224.pdf

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