γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes-Reference-Cited by-同舟云学术

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes

Published:2015-04-09 Issue:15 Volume:125 Page:2349-2358
ISSN:0006-4971
Container-title:Blood
language:en
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Author:

Airoldi Irma¹,Bertaina Alice²,Prigione Ignazia¹,Zorzoli Alessia¹,Pagliara Daria²,Cocco Claudia¹,Meazza Raffaella³,Loiacono Fabrizio⁴,Lucarelli Barbarella²,Bernardo Maria Ester²,Barbarito Giulia¹,Pende Daniela³,Moretta Alessandro⁵,Pistoia Vito¹,Moretta Lorenzo⁶,Locatelli Franco²⁷

Affiliation:

1. Laboratorio di Oncologia, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Giannina Gaslini, Genova, Italy;

2. Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children’s Hospital, Rome, Italy;

3. Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino–Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy;

4. Core Facilities, Istituto Giannina Gaslini, Genova, Italy;

5. Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Università di Genova, Genova, Italy;

6. Istituto Giannina Gaslini, Genova, Italy; and

7. Department of Pediatric Science, University of Pavia, Pavia, Italy

Abstract

Key Points Vδ1 and Vδ2 T cells promptly reconstitute in children given haploidentical stem cell transplantation depleted of αβ+ T and CD19+ B cells. Vδ1 cells are expanded in patients experiencing cytomegalovirus reactivation; ZOL potentiates Vδ2 killing against leukemia blasts.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/15/2349/1384340/2349.pdf

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5. Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem-cell transplantation.;Bari;J Clin Oncol,2013

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