HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation

Author:

Petersdorf Effie W.12,Gooley Theodore A.1,Malkki Mari1,Bacigalupo Andrea P.3,Cesbron Anne4,Du Toit Ernette5,Ehninger Gerhard6,Egeland Torstein7,Fischer Gottfried F.8,Gervais Thibaut9,Haagenson Michael D.10,Horowitz Mary M.11,Hsu Katharine12,Jindra Pavel13,Madrigal Alejandro14,Oudshoorn Machteld15,Ringdén Olle16,Schroeder Marlis L.17,Spellman Stephen R.10,Tiercy Jean-Marie18,Velardi Andrea19,Witt Campbell S.20,O’Huigin Colm21,Apps Richard2122,Carrington Mary2122

Affiliation:

1. Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Department of Medicine, University of Washington School of Medicine, Seattle, WA;

3. Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino, Genova, Italy;

4. Laboratoire d'Histocompatibilité et d'Immunogénétique, Etablissement Français du Sang Pays de Loire, Nantes, France;

5. University of Cape Town, Cape Town and South African Bone Marrow Registry, Cape Town, South Africa;

6. Universitätsklinikum Carl Gustav Carus, Dresden, Germany;

7. Department of Immunology, Oslo University Hospital, Oslo, Norway;

8. Department for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria;

9. Cliniques St. Luc, Université Catholique de Louvain, Brussels, Belgium;

10. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

11. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

12. Memorial Sloan-Kettering Cancer Center, New York, NY;

13. University Hospital, Pilsen, Czech Republic;

14. Anthony Nolan Research Institute, The Royal Free Hampstead NHS Trust, London, United Kingdom;

15. Leiden University Medical Center and Europdonor Foundation, Leiden, The Netherlands;

16. Division of Therapeutic Immunology, Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Huddinge, Sweden;

17. Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada;

18. National Reference Laboratory for Histocompatibility, Department of Genetics and Laboratory Medicine, University Hospital Geneva, Geneva, Switzerland;

19. European Group for Blood and Marrow Transplantation and University of Perugia, Perugia, Italy;

20. Department of Clinical Immunology, Royal Perth Hospital, Perth, Australia;

21. Cancer and Inflammation Program, SAIC Frederick, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD; and

22. Ragon Institute of the Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA

Abstract

Key Points The expression level of patient HLA-C allotypes affects GVHD and mortality after HCT from HLA-C-mismatched unrelated donors. Transplant outcome can be improved by avoiding high-risk HLA-C-mismatched donors when no matched stem cell source is available.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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