Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production-Reference-Cited by-同舟云学术

Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production

Published:2013-05-23 Issue:21 Volume:121 Page:4413-4416
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Safdar Huma¹²,Cheung Ka Lei¹²,Salvatori Daniela³,Versteeg Henri H.¹²,Laghmani El Houari⁴,Wagenaar Gerry T. M.⁴,Reitsma Pieter H.¹²,van Vlijmen Bart J. M.¹²

Affiliation:

1. Einthoven Laboratory for Experimental Vascular Medicine,

2. Department of Thrombosis and Hemostasis,

3. Central Laboratory Animal Facility, and

4. Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Key Points RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes, alone or in combination, in normal adult mice. RNA interference of Serpinc1 and Proc provides a novel, controlled mouse model for spontaneous venous thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/21/4413/1366232/4413.pdf

Reference6 articles.

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3. Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.;Safdar;PLoS ONE,2012

4. Revised guides for organ sampling and trimming in rats and mice—part 1.;Ruehl-Fehlert;Exp Toxicol Pathol,2003

5. 17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α.;Cleuren;J Thromb Haemost,2010

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