Interleukin-7 promotes HIV persistence during antiretroviral therapy-Reference-Cited by-同舟云学术

Interleukin-7 promotes HIV persistence during antiretroviral therapy

Published:2013-05-23 Issue:21 Volume:121 Page:4321-4329
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vandergeeten Claire¹,Fromentin Rémi¹,DaFonseca Sandrina¹,Lawani Mariam B.¹,Sereti Irini²,Lederman Michael M.³,Ramgopal Moti⁴,Routy Jean-Pierre⁵,Sékaly Rafick-Pierre¹,Chomont Nicolas¹

Affiliation:

1. Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL;

2. Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

3. Case Western Reserve University, University Hospitals/Case Medical Center, Cleveland, OH;

4. Midway Immunology & Research Center, Fort Pierce, FL; and

5. Division of Hematology and Chronic Viral Illness Service, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada

Abstract

Key Points IL-7 does not disrupt viral latency in highly pure resting latently infected CD4+ T cells from HIV-infected subjects receiving ART. IL-7 therapy leads to a 70% increase in the absolute number of circulating CD4+ T cells harboring integrated HIV DNA 4 weeks posttherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/21/4321/1365650/4321.pdf

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