c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells-Reference-Cited by-同舟云学术

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Published:2014-02-13 Issue:7 Volume:123 Page:1040-1050
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Roderick Justine E.¹,Tesell Jessica¹,Shultz Leonard D.²,Brehm Michael A.³,Greiner Dale L.³,Harris Marian H.⁴,Silverman Lewis B.⁵,Sallan Stephen E.⁵,Gutierrez Alejandro⁴⁵,Look A. Thomas⁴⁵,Qi Jun⁶,Bradner James E.⁶,Kelliher Michelle A.¹

Affiliation:

1. Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA;

2. The Jackson Laboratory, Bar Harbor, ME;

3. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA;

4. Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA;

5. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and

6. Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Jerome Lipper Multiple Myeloma Center, Boston, MA

Abstract

Key Points c-Myc is required for leukemia-initiating cell maintenance in murine models of T-ALL. c-Myc inhibition prevents the growth of treatment-resistant primary T-ALL patient samples in vitro.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/7/1040/537943/1040.pdf

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