Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD-Reference-Cited by-同舟云学术

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD

Published:2015-04-23 Issue:17 Volume:125 Page:2720-2723
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dertschnig Simone¹,Hauri-Hohl Mathias M.²,Vollmer Madeleine³,Holländer Georg A.¹⁴,Krenger Werner³

Affiliation:

1. Department of Biomedicine, University of Basel and Basel University Children’s Hospital, Basel, Switzerland;

2. Benaroya Research Institute, Virginia Mason Hospital, Seattle, Washington;

3. Department of Biomedicine, University Hospital Basel, Basel, Switzerland; and

4. Department of Paediatrics and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

Abstract

Key Points Loss of thymic ectopic self-antigen expression during murine acute GVHD is responsible for the de novo generation of autoreactive T cells. Functional impairment of the thymus medulla mechanistically links acute GVHD to posttransplantation autoimmunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/17/2720/1385594/2720.pdf

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