The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice-Reference-Cited by-同舟云学术

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

Published:2015-03-26 Issue:13 Volume:125 Page:2075-2078
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stewart Morag H.¹²,Albert Mareike³,Sroczynska Patrycja³,Cruickshank V. Adam³,Guo Yanping⁴,Rossi Derrick J.¹²,Helin Kristian³,Enver Tariq⁴

Affiliation:

1. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA;

2. Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA;

3. Biotech Research and Innovation Center, Center for Epigenetics, and The Danish Stem Cell Center, University of Copenhagen, Copenhagen, Denmark; and

4. Stem Cell Group, University College London Cancer Institute, University College London, London, United Kingdom

Abstract

Key Points Jarid1b is not required for steady-state hematopoiesis. Jarid1b is required for HSC self-renewal.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/13/2075/1383540/2075.pdf

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2. Transcriptional regulation of haematopoietic stem cells.;Wilkinson;Adv Exp Med Biol,2013

3. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.;Beerman;Cell Stem Cell,2013

4. Large conserved domains of low DNA methylation maintained by Dnmt3a.;Jeong;Nat Genet,2014

5. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.;Kerenyi;eLife,2013

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