Prolylcarboxypeptidase promotes angiogenesis and vascular repair

Author:

Adams Gregory N.1,Stavrou Evi X.1,Fang Chao1,Merkulova Alona1,Alaiti M. Amer23,Nakajima Kohsuke23,Morooka Toshifumi23,Merkulov Sergei1,LaRusch Gretchen A.1,Simon Daniel I23,Jain Mukesh K.23,Schmaier Alvin H.1

Affiliation:

1. Department of Medicine, Hematology and Oncology Division,

2. Case Cardiovascular Institute, and

3. Harrington Heart & Vascular Institute, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH

Abstract

Key Points PRCP influences cell growth independent of its active site. PRCP loss has reduced angiogenesis, wound healing, and ischemic/wire injury repair.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference47 articles.

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3. Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator.;Shariat-Madar;J Biol Chem,2002

4. Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.;Wallingford;J Clin Invest,2009

5. Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney.;Odya;J Biol Chem,1978

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