Selective killing of candidate AML stem cells by antibody targeting of IL1RAP-Reference-Cited by-同舟云学术

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

Published:2013-05-02 Issue:18 Volume:121 Page:3709-3713
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Askmyr Maria¹,Ågerstam Helena¹,Hansen Nils¹,Gordon Sandra¹,Arvanitakis Alexandros¹,Rissler Marianne¹,Juliusson Gunnar²,Richter Johan³,Järås Marcus¹,Fioretos Thoas¹

Affiliation:

1. Department of Clinical Genetics, University and Regional Laboratories, Lund University, Lund, Sweden;

2. Hematology/Transplantation, Stem Cell Center, Lund University and Department of Hematology and Coagulation, Skåne University Hospital, Lund, Sweden; and

3. Department of Molecular Medicine and Gene Therapy, Lund University and Department of Hematology and Coagulation, Skåne University Hospital, Lund, Sweden

Abstract

Key Points IL1RAP is overexpressed on candidate AML stem cells and is a promising target for antibody-based therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/18/3709/1363482/3709.pdf

Reference11 articles.

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2. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases.;Dinarello;Nat Rev Drug Discov,2012

3. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.;Järås;Proc Natl Acad Sci USA,2010