Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice-Reference-Cited by-同舟云学术

Anti–miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice

Published:2015-12-24 Issue:26 Volume:126 Page:2871-2881
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhou Yuhang¹^ORCID,Abraham Shaji¹^ORCID,Andre Pierrette¹,Edelstein Leonard C.¹^ORCID,Shaw Chad A.²^ORCID,Dangelmaier Carol A.³,Tsygankov Alexander Y.³,Kunapuli Satya P.³,Bray Paul F.¹,McKenzie Steven E.¹

Affiliation:

1. Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA;

2. Baylor College of Medicine, Houston, TX; and

3. Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, PA

Abstract

Key Points TULA-2 negatively regulates platelet FcγRIIA signaling by dephosphorylating Syk. miR-148a targets TULA-2 and inhibition of miR-148a decreases FcγRIIA-mediated platelet activation and thrombosis in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/26/2871/1391061/2871.pdf

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