Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice-Reference-Cited by-同舟云学术

Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice

Published:2016-09-22 Issue:12 Volume:128 Page:1642-1650
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kristofik Nina¹,Calabro Nicole E.²,Tian Weiming²,Meng Aaron¹,MacLauchlan Susan²,Wang Yinong²³,Breuer Christopher K.⁴,Tellides George³,Niklason Laura E.¹⁵,Kyriakides Themis R.¹²

Affiliation:

1. Department of Biomedical Engineering, School of Engineering and Applied Science,

2. Department of Pathology, and

3. Department of Surgery, School of Medicine, Yale University, New Haven, CT;

4. Department of Surgery, Nationwide Children’s Hospital, Columbus, OH; and

5. Department of Anesthesiology, School of Medicine, Yale University, New Haven, CT

Abstract

Key Points Irregular ECM assembly in TSP2 KO mice results in reduced VWF adhesion and compromised platelet function. Because overall ECM composition is not altered, this study highlights the importance of ECM organization in hemostasis and thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/12/1642/1395983/1642.pdf

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