The activation peptide cleft exposed by thrombin cleavage of FXIII-A2 contains a recognition site for the fibrinogen α chain-Reference-Cited by-同舟云学术

The activation peptide cleft exposed by thrombin cleavage of FXIII-A2 contains a recognition site for the fibrinogen α chain

Published:2013-03-14 Issue:11 Volume:121 Page:2117-2126
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Smith Kerrie A.¹,Pease Richard J.¹,Avery Craig A.²,Brown Jane M.¹,Adamson Penelope J.¹,Cooke Esther J.¹,Neergaard-Petersen Søs¹³,Cordell Paul A.¹,Ariëns Robert A. S.¹,Fishwick Colin W. G.²,Philippou Helen¹,Grant Peter J.¹

Affiliation:

1. Division of Cardiovascular and Diabetes Research, Faculty of Medicine and Health, and

2. School of Chemistry, Multi-Disciplinary Cardiovascular Research Centre, University of Leeds, Leeds, United Kingdom; and

3. Department of Cardiology, Aarhus University Hospital, Skejby, Denmark

Abstract

Key PointsFibrin αC389-402 binds a cleft in the β-sandwich domain of FXIII-A2* exposed only after cleavage of the activation peptide. Binding of fibrin αC389-402 to FXIII-A2* regulates fibrin cross-linking and thus clot stabilization and fibrinolysis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/11/2117/1364124/2117.pdf

Reference40 articles.

1. Contribution of fibrin stabilization to clot strength. Supplementation of factor XIII-deficient plasma with the purified zymogen.;Shen;J Clin Invest,1983

2. A study of human coagulation factor XIII A-subunit by electrospray ionisation mass spectrometry.;Ashcroft;Rapid Commun Mass Spectrom,2000

3. Blood coagulation factor XIII: structure and function.;Muszbek;Thromb Res,1999

4. Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin.;Schwartz;J Biol Chem,1973

5. Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin.;Takagi;Biochemistry,1974

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