Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients-Reference-Cited by-同舟云学术

Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients

Published:2013-02-07 Issue:6 Volume:121 Page:1039-1048
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Whelan Shawn F. J.¹,Hofbauer Christoph J.¹,Horling Frank M.¹,Allacher Peter¹,Wolfsegger Martin J.¹,Oldenburg Johannes²,Male Christoph³,Windyga Jerzy⁴,Tiede Andreas⁵,Schwarz Hans Peter¹,Scheiflinger Friedrich¹,Reipert Birgit M.¹

Affiliation:

1. Baxter Innovation GmbH, Vienna, Austria;

2. Institute for Experimental Hematology and Transfusion Medicine, Bonn, Germany;

3. Department of Pediatrics, Medical University of Vienna, Vienna, Austria;

4. Institute of Hematology and Transfusion Medicine, Warsaw, Poland; and

5. Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

Abstract

Key Points Antibodies against factor VIII show distinct characteristics in healthy individuals and different cohorts of hemophilia A patients. IgG4 antibodies against FVIII are only found in patients with inhibitors but not in healthy individuals or patients without inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/1039/1367913/zh800613001039.pdf

Reference46 articles.

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3. FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting.;Fulcher;Blood,1987

4. Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses.;Ettinger;Blood,2009

5. Prevention and treatment of factor VIII inhibitors in murine hemophilia A.;Qian;Blood,2000

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