Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results

Author:

Dastugue Nicole1,Suciu Stefan2,Plat Geneviève3,Speleman Frank4,Cavé Hélène56,Girard Sandrine7,Bakkus Marleen8,Pagès Marie Pierre7,Yakouben Karima9,Nelken Brigitte10,Uyttebroeck Anne11,Gervais Carine12,Lutz Patrick13,Teixeira Manuel R.14,Heimann Pierre15,Ferster Alice16,Rohrlich Pierre17,Collonge Marie Agnès18,Munzer Martine19,Luquet Isabelle20,Boutard Patrick21,Sirvent Nicolas22,Karrasch Matthias2,Bertrand Yves23,Benoit Yves24

Affiliation:

1. Hematology Laboratory, Purpan Hospital, Toulouse, France;

2. European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium;

3. Department of Hematology, Children’s Hospital, Toulouse, France;

4. Center for Medical Genetics, Universiteit Ziekenhuis, Ghent, Belgium;

5. Department of Genetics, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France;

6. Paris-Diderot University, Paris, France;

7. Hematology Laboratory, Lyon Sud Hospital, Lyon, France;

8. Molecular Hematology Laboratory, UZ Brussels, Brussels, Belgium;

9. Department of Hemato-Immunology, Robert Debré Hospital, Paris, France;

10. University Lille Nord de France and Pediatric Hematology Unit, Centre Hospitalier Universitaire, Lille, France;

11. Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium;

12. Hematology Laboratory, Hautepierre, Strasbourg, France;

13. Department of Pediatric Hematology, Hautepierre, Strasbourg, France;

14. Department of Genetics, Portuguese Oncology Institute, Porto and Biomedical Sciences Institute, University of Porto, Porto, Portugal;

15. Laboratory of Cytogenetics, Bordet Institute, Brussels, Belgium;

16. Department of Hemato-Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium;

17. Department of Pediatric Hematology-Oncology, Centre Hospitalier Universitaire, Besançon, France;

18. Department of Genetics, Centre Hospitalier Universitaire, Besançon, France;

19. Department of Pediatric Hematology-Oncology and

20. Hematology Laboratory, Centre Hospitalier Universitaire, Reims, France;

21. Department of Pediatric Hematology-Oncology, Centre Hospitalier Universitaire, Caen, France;

22. Department of Pediatric Hematology-Oncology, Centre Hospitalier Universitaire, Nice, France;

23. Department of Immuno-Hemato-Pediatrics, Hospices Civils de Lyon et Université Claude Bernard, Lyon, France; and

24. Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium

Abstract

Key Points Patients with 58-66 chromosomes have 99% event-free survival and 100% overall survival in the 58951 EORTC-CLG study. The higher the ploidy, the better the prognosis in the 58951 EORTC-CLG study.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference30 articles.

1. Chromosomal findings and their correlation to prognosis in acute lymphocytic leukemia.;Kaneko;Cancer Genet Cytogenet,1981

2. Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia.;Williams;Blood,1982

3. Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia.;Moorman;Blood,2003

4. Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia.;Raimondi;Leukemia,1996

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