Rapid activation receptor– or IL-2–induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling-Reference-Cited by-同舟云学术

Rapid activation receptor– or IL-2–induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

Published:2013-04-04 Issue:14 Volume:121 Page:2627-2637
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

James Ashley Mentlik¹,Hsu Hsiang-Ting²,Dongre Prachi²,Uzel Gulbu³,Mace Emily M.²,Banerjee Pinaki P.²⁴,Orange Jordan S.²⁴

Affiliation:

1. Graduate Program in Cell Biology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA;

2. Center for Human Immunobiology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX;

3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Laboratory of Clinical Infectious Disease, Bethesda, MD; and

4. Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX

Abstract

Key PointsSrc signals are required for specific receptor and cytokine activation–induced rapid reorientation of lytic granules to the MTOC in NK cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/14/2627/1365021/2627.pdf

Reference46 articles.

1. NK cell development, homeostasis and function: parallels with CD8⁺ T cells.;Sun;Nat Rev Immunol,2011

2. Formation and function of the lytic NK-cell immunological synapse.;Orange;Nat Rev Immunol,2008

3. Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.;Mentlik;Mol Biol Cell,2010

4. Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.;Rak;PLoS Biol,2011

5. JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity.;Li;Proc Natl Acad Sci USA,2008

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