Alternative donor hematopoietic cell transplantation for Fanconi anemia

Author:

MacMillan Margaret L.12,DeFor Todd E.13,Young Jo-Anne H.4,Dusenbery Kathryn E.5,Blazar Bruce R.12,Slungaard Arne14,Zierhut Heather6,Weisdorf Daniel J.14,Wagner John E.12

Affiliation:

1. Blood and Marrow Transplant Program,

2. Department of Pediatrics,

3. Biostatistics and Informatics Core, Masonic Cancer Center,

4. Department of Medicine,

5. Department of Therapeutic Radiology, and

6. Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN

Abstract

Key Points With no prior opportunistic infections/transfusions, 5-year survival after alternative donor HCT with TBI 300 cGy, CY, FLU, and ATG was 94%. Today, most FA patients with standard risk disease are cured of their bone marrow failure by HCT even without an HLA-matched sibling donor.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference40 articles.

1. Familial constitutional panmyelocytopathy, Fanconi’s anemia (F.A.). I. Clinical aspects.;Fanconi;Semin Hematol,1967

2. Hematologic abnormalities in Fanconi anemia: an International Fanconi Anemia Registry study.;Butturini;Blood,1994

3. A 20-year perspective on the International Fanconi Anemia Registry (IFAR).;Kutler;Blood,2003

4. Hematopoietic Cell Transplantation for Fanconi's Anemia.;Wagner,2008

5. Bone marrow transplantation for Fanconi anemia.;Gluckman;Blood,1995

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