CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells-Reference-Cited by-同舟云学术

CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells

Published:2015-04-09 Issue:15 Volume:125 Page:2381-2385
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Amé-Thomas Patricia¹²³⁴^ORCID,Hoeller Sylvia⁵⁶⁷,Artchounin Catherine⁶⁷⁸,Misiak Jan¹²³,Braza Mounia Sabrina¹²³,Jean Rachel¹²³⁴,Le Priol Jérôme¹²³,Monvoisin Céline¹²³,Martin Nadine⁶⁷,Gaulard Philippe⁶⁷⁸,Tarte Karin¹²³⁴

Affiliation:

1. INSERM, Unité Mixte de Recherche U917, Equipe Labellisée Ligue Contre le Cancer, Rennes, France;

2. Université Rennes 1, Unité Mixte de Recherche U917, Rennes, France;

3. Etablissement Français du Sang Bretagne, Rennes, France;

4. Centre Hospitalier Universitaire de Rennes, Service d'Immunologie, Thérapie Cellulaire et Hématopoïèse, Rennes, France;

5. Institute for Pathology, University Hospital Basel, Switzerland;

6. INSERM U955, Créteil, France;

7. Université Paris-Est, Créteil, France; and

8. Hôpital Henri Mondor, Département de Pathologie, Assistance Publique - Hôpitaux de Paris, Créteil, France

Abstract

Key Points CD10 identifies a unique subset of fully functional germinal center TFH that are activated and amplified within the FL cell niche. FL CD10pos TFH specifically display an IL-4hiIFN-γlo cytokine profile and encompass the malignant B-cell-supportive TFH subset.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/15/2381/1384044/2381.pdf

Reference24 articles.

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