A role for IRF4 in the development of CLL-Reference-Cited by-同舟云学术

A role for IRF4 in the development of CLL

Published:2013-10-17 Issue:16 Volume:122 Page:2848-2855
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shukla Vipul¹,Ma Shibin¹,Hardy Richard R.²,Joshi Shantaram S.¹,Lu Runqing¹

Affiliation:

1. Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE; and

2. Fox Chase Cancer Center, Philadelphia, PA

Abstract

Key Points IRF4−/−Vh11 mice develop spontaneous CLL at 100% penetrance, indicating that a low level of IRF4 is critical for CLL development. IRF4−/−Vh11 mice are a novel mouse model of CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/16/2848/1369423/2848.pdf

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5. Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development.;Ma;Blood,2008

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