Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice-Reference-Cited by-同舟云学术

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

Published:2013-08-08 Issue:6 Volume:122 Page:1052-1061
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kim Kyungho¹,Hahm Eunsil¹,Li Jing¹²,Holbrook Lisa-Marie³,Sasikumar Parvathy³,Stanley Ronald G.³,Ushio-Fukai Masuko¹⁴,Gibbins Jonathan M.³,Cho Jaehyung¹²

Affiliation:

1. Department of Pharmacology, and

2. Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL;

3. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom; and

4. Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL

Abstract

Key Points Platelet PDI regulates αIIbβ3 integrin activation without affecting platelet activation and inside-out integrin signaling. Platelet PDI is essential for platelet accumulation but not for fibrin generation and hemostasis in mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/6/1052/1376082/1052.pdf

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4. The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity.;O’Neill;J Biol Chem,2000

5. A redox site involved in integrin activation.;Yan;J Biol Chem,2000

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