Clinical characteristics and outcomes of therapy-related chronic myelomonocytic leukemia

Author:

Takahashi Koichi12,Pemmaraju Naveen3,Strati Paolo3,Nogueras-Gonzalez Graciela4,Ning Jing4,Bueso-Ramos Carlos5,Luthra Rajyalakshmi5,Pierce Sherry3,Cortes Jorge3,Kantarjian Hagop3,Garcia-Manero Guillermo3

Affiliation:

1. Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; and

3. Department of Leukemia,

4. Department of Biostatistics, and

5. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points t-CMML is associated with higher-risk cytogenetics and manifests poor prognosis. t-CMML should be recognized as one of the therapy-related myeloid neoplasms.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference14 articles.

1. The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia.;Bennett;Br J Haematol,1994

2. Therapy related CMML: a case report and review of the literature.;Ahmed;Int J Hematol,2009

3. Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.;Knipp;Haematologica,2005

4. Three cases of multiple myeloma developing into melphalan-related chronic myelomonocytic leukemia.;Ueki;J Med,1991

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