Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding-Reference-Cited by-同舟云学术

Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding

Published:2017-06-15 Issue:24 Volume:129 Page:3210-3220
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Belderbos Mirjam E.¹²³,Koster Taco¹,Ausema Bertien¹,Jacobs Sabrina¹,Sowdagar Sharlaine¹,Zwart Erik¹,de Bont Eveline⁴,de Haan Gerald¹,Bystrykh Leonid V.¹

Affiliation:

1. Department of Stem Cell Biology and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

2. Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands;

3. Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; and

4. Department of Pediatric Oncology/Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Abstract

Key Points Patient-derived leukemia xenografts are highly polyclonal and show stochastic and clone-size–driven selection. Leukemia clones are asymmetrically distributed in xenografts and preferentially localize to the bone marrow or to extramedullary sites.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/24/3210/1401365/blood758250.pdf

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