CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies-Reference-Cited by-同舟云学术

CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies

Published:2017-07-20 Issue:3 Volume:130 Page:297-309
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Al Sayed Mohamad F.¹^ORCID,Ruckstuhl Carla A.¹,Hilmenyuk Tamara¹,Claus Christina¹,Bourquin Jean-Pierre²^ORCID,Bornhauser Beat C.²^ORCID,Radpour Ramin¹^ORCID,Riether Carsten¹³^ORCID,Ochsenbein Adrian F.¹³^ORCID

Affiliation:

1. Tumor Immunology, Department of Clinical Research, University of Bern, Bern, Switzerland;

2. Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland; and

3. Department of Medical Oncology, Inselspital, University Hospital and University of Bern, Bern, Switzerland

Abstract

Key Points CD27 expression on malignant B cells triggers CD70 reverse signaling in NK cells and improves lymphoma immunosurveillance. CD70 reverse signaling in NK cells is mediated via the AKT signaling pathway and enhances survival and effector function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/3/297/1404839/blood756585.pdf

Reference69 articles.

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4. CD27 is required for generation and long-term maintenance of T cell immunity;Hendriks;Nat Immunol,2000

5. CD27-mediated activation of murine NK cells;Takeda;J Immunol,2000

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