Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease-Reference-Cited by-同舟云学术

Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease

Published:2016-05-05 Issue:18 Volume:127 Page:2203-2213
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chapuy Bjoern¹,Cheng Hongwei²,Watahiki Akira²,Ducar Matthew D.³,Tan Yuxiang⁴,Chen Linfeng¹,Roemer Margaretha G. M.¹,Ouyang Jing¹,Christie Amanda L.¹,Zhang Liye⁴,Gusenleitner Daniel⁴,Abo Ryan P.³,Farinha Pedro⁵,von Bonin Frederike⁶,Thorner Aaron R.³,Sun Heather H.⁷,Gascoyne Randy D.⁵,Pinkus Geraldine S.⁷,van Hummelen Paul³,Wulf Gerald G.⁶,Aster Jon C.⁷,Weinstock David M.¹,Monti Stefano⁴,Rodig Scott J.⁷,Wang Yuzhuo²,Shipp Margaret A.¹

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

2. Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, BC, Canada;

3. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA;

4. Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA;

5. Department of Pathology and Laboratory Medicine and the Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

6. Department of Hematology and Oncology, Georg-August University Goettingen, Goettingen, Germany; and

7. Department of Pathology, Brigham and Women’s Hospital, Boston, MA

Abstract

Key Points Our generated PDX models reflect the immunophenotypic, transcriptional, genetic, and functional heterogeneity of primary DLBCL. The experimental and analytical approach will inform the development of additional PDX models and facilitate preclinical drug discovery.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/18/2203/1392993/2203.pdf

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