EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications-Reference-Cited by-同舟云学术

EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications

Published:2016-05-05 Issue:18 Volume:127 Page:2214-2218
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Schwab Claire¹,Ryan Sarra L.¹,Chilton Lucy¹^ORCID,Elliott Alannah¹,Murray James¹,Richardson Stacey¹,Wragg Christopher²,Moppett John³,Cummins Michelle³,Tunstall Oliver³,Parker Catriona A.⁴,Saha Vaskar⁴⁵,Goulden Nicholas⁶,Vora Ajay⁷,Moorman Anthony V.¹,Harrison Christine J.¹

Affiliation:

1. Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom;

2. Bristol Genetics Laboratory, Southmead Hospital, North Bristol National Health Service Trust, Bristol, United Kingdom;

3. Department of Paediatric Haematology and Oncology, Bristol Royal Hospital for Children, Bristol, United Kingdom;

4. Children’s Cancer Group, Manchester Academic Health Sciences Centre, Institute of Cancer, University of Manchester, Manchester, United Kingdom;

5. Department of Paediatric Oncology, Tata Translational Cancer Research Centre, Kolkata, India;

6. Department of Haematology, Great Ormond Street Hospital, London, United Kingdom; and

7. Department of Haematology, Sheffield Children’s Hospital, Sheffield, United Kingdom

Abstract

Key Points EBF1-PDGFRB fusion accounts for ∼0.5% of B-cell precursor acute lymphoblastic leukemia and 2.7% of the B-other subtype. EBF1-PDGFRB-positive patients are MRD positive and are slow early responders who respond to imatinib.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/18/2214/1392967/2214.pdf

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