IκB kinase phosphorylation of SNAP-23 controls platelet secretion-Reference-Cited by-同舟云学术

IκB kinase phosphorylation of SNAP-23 controls platelet secretion

Published:2013-05-30 Issue:22 Volume:121 Page:4567-4574
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Karim Zubair A.¹,Zhang Jinchao¹,Banerjee Meenakshi¹,Chicka Michael C.¹,Al Hawas Rania¹,Hamilton Tara R.¹,Roche Paul A.²,Whiteheart Sidney W.¹

Affiliation:

1. Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY; and

2. Experimental Immunology Branch, National Cancer Institute, Bethesda, MD

Abstract

Key Points Nongenomic role for IκB kinase in platelet secretion: IKK phosphorylates SNAP-23, which affects granule-plasma membrane fusion. Pharmacologic inhibition or deletion of platelet IKK affects bleeding times.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/22/4567/1365823/4567.pdf

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