Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL

Author:

Rego Eduardo M.1,Kim Haesook T.2,Ruiz-Argüelles Guillermo J.3,Undurraga Maria Soledad4,Uriarte Maria del Rosario5,Jacomo Rafael H.1,Gutiérrez-Aguirre Homero6,Melo Raul A. M.7,Bittencourt Rosane8,Pasquini Ricardo9,Pagnano Katia10,Fagundes Evandro M.11,Chauffaille Maria de Lourdes12,Chiattone Carlos S.13,Martinez Lem5,Meillón Luis A.14,Gómez-Almaguer David6,Kwaan Hau C.15,Garcés-Eisele Javier3,Gallagher Robert16,Niemeyer Charlotte M.17,Schrier Stanley L.18,Tallman Martin19,Grimwade David20,Ganser Arnold21,Berliner Nancy22,Ribeiro Raul C.23,Lo-Coco Francesco2425,Löwenberg Bob26,Sanz Miguel A.27

Affiliation:

1. Hematology/Oncology Division, Department of Internal Medicine, Medical School of Ribeirão Preto and Center for Cell Based Therapy, University of São Paulo, Ribeirão Preto, Brazil;

2. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA;

3. Clinica Ruiz de Puebla, Puebla, México;

4. Department of Hematology, Hospital del Salvador, Santiago, Chile;

5. Asociación Española Primera de Socorros Mutuos, Montevideo, Uruguay;

6. Hematology Division, Hospital Universitario Dr José E. González, Monterrey, Mexico;

7. Fundação HEMOPE, Recife, Brazil;

8. Hematology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

9. Hematology Division, Federal University of Paraná, Curitiba, Brazil;

10. Hematology and Hemotherapy Center, University of Campinas UNICAMP, Campinas, Brazil;

11. Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil;

12. Hematology and Transfusion Medicine, Federal University of São Paulo, São Paulo, Brazil;

13. Hematology Division, Santa Casa Medical School, São Paulo, Brazil;

14. Centro Médico Nacional Siglo XXI, Mexico City, Mexico;

15. Hematology/Oncology Division, Northwestern University, Feinberg School of Medicine, Chicago, IL;

16. Medicine and Oncology, Albert Einstein Cancer Center, New York, NY;

17. Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany;

18. Department of Medicine, Stanford University, Stanford, CA;

19. Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY;

20. Department of Medical and Molecular Genetics, King’s College London School of Medicine, London, United Kingdom;

21. Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;

22. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;

23. Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN;

24. Department of Biopathology, University Tor Vergata and

25. Santa Lucia Foundation, Rome, Italy;

26. Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands; and

27. Department of Hematology, Hospital Universitario La Fe, Valencia University Medical School, Valencia, Spain

Abstract

Key Points For patients in developing countries with APL, a clinical network of institutions made it possible to reduce significantly the early mortality and improve the OS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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