Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress

Author:

Pantaleo Antonella1ORCID,Kesely Kristina R.2,Pau Maria Carmina1,Tsamesidis Ioannis3ORCID,Schwarzer Evelin4,Skorokhod Oleksii A.4,Chien Huynh D.5,Ponzi Marta67,Bertuccini Lucia78,Low Philip S.2,Turrini Francesco M.4

Affiliation:

1. Department of Biomedical Sciences, University of Sassari, Sassari, Italy;

2. Purdue Center for Drug Discovery and Department of Chemistry, Purdue University, West Lafayette, IN;

3. Department of Medicine, University of Verona, Verona, Italy;

4. Department of Oncology, University of Turin, Turin, Italy;

5. Biomedical Institute, Medical School, University of Hue, Hue City, Vietnam; and

6. Department of Infectious Diseases,

7. Core Facilities, and

8. National Center for Innovative Technologies in Public Health, National Institutes of Health, Rome, Italy

Abstract

Key PointsInhibitors of human Syk kinase suppress parasite egress. Syk inhibitors prevent the tyrosine phosphorylation of band 3 in P falciparum parasitized red blood cells, reducing the release of microparticles.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference75 articles.

1. Eliminating Malaria; 2016;WHO,2016

2. Artemisinin and artemisinin-based combination therapy resistance;WHO,2016

3. Artemisinin and artemisinin-based combination therapy resistance;WHO,2016

4. Artemisinin resistance, some facts and opinions;Pantaleo;J Infect Dev Ctries,2015

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