Bim regulates the survival and suppressive capability of CD8+ FOXP3+ regulatory T cells during murine GVHD-Reference-Cited by-同舟云学术

Bim regulates the survival and suppressive capability of CD8+ FOXP3+ regulatory T cells during murine GVHD

Published:2018-07-26 Issue:4 Volume:132 Page:435-447
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agle Kimberle¹,Vincent Benjamin G.²³,Piper Clint¹,Belle Ludovic¹,Zhou Vivian¹,Shlomchik Warren⁴,Serody Jonathan S.²,Drobyski William R.¹

Affiliation:

1. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI;

2. Department of Microbiology/Immunology and

3. Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC; and

4. Department of Medicine, University of Pittsburgh, Pittsburgh, PA

Abstract

Key Points CD8+ Tregs possess a proapoptotic phenotype when compared with CD4+ Tregs, which is characterized by an inversion of the Bim/Mcl-1 ratio. Absence of Bim in adoptively transferred CD8+ Tregs results in augmented in vivo survival and superior protection from GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/4/435/1407338/blood807156.pdf

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