Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming Cell-Reference-Cited by-同舟云学术

Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming Cell

Published:1974-03-01 Issue:3 Volume:43 Page:363-369
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ratzan R. Judith¹²,Moore Malcolm A. S.¹³,Yunis Adel A.¹⁴

Affiliation:

1. Department of Medicine, University of Miami School of Medicine and The Howard Hughes Medical Institute, Miami, Fla. 33152, and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

2. University of Miami School of Medicine, Miami, Fla. 33152.

3. Cancer Research Unit, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

4. Division of Hematology. University of Miami School of Medicine and The Howard Hughes Laboratories for Hematological Research. Miami. Fla. 33152.

Abstract

Abstract The effect of chloramphenicol and a chloramphenicol analog, thiamphenicol, on the growth of bone marrow colony-forming cells in agar was investigated. At concentrations within therapeutic range, both drugs cause a marked reduction in the number of colonies and in the size of aggregates, indicating suppressed cellular proliferation. The inhibition appears to be reversible within a 24-hr period of cell-drug contact. In addition to their effect on CFC proliferation, CAP and TAP appear to influence the type of CFC differentiation resulting in predominance of macrophage colonies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/43/3/363/578707/363.pdf

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