Serum Concentrations of Vitamin B12 in Patients Suffering from Leukemia-Reference-Cited by-同舟云学术

Serum Concentrations of Vitamin B12 in Patients Suffering from Leukemia

Published:1954-08-01 Issue:8 Volume:9 Page:789-794
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

BEARD MARION F.¹,PITNEY W. R.¹,SANNEMAN E. H.¹

Affiliation:

1. Section of Hematology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.

Abstract

Abstract 1. Vitamin B12 serum concentrations have been investigated in various types Of leukemia. 2. The concentration in chronic myeloid leukemia is approximately 15 times normal. In chronic lymphatic leukemia it is normal. In acute leukemia it is variable. 3. In chronic myeloid leukemia, the serum vitamim B12 exists in the bound form and the binding capacity for added B12 is increased. 4. Electrophoretic studies indicate that serum vitamims B12 in chronic myeloid leukemia is bound in the alpha globulin fractions. 5. Some correlation was found between serum vitamin B12 concentrations and total white cell counts in chronic myeloid leukemia. The possible significance of this is discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/9/8/789/623117/789.pdf

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