Molecular analysis of human anti-factor VIII antibodies by V gene phage display identifies a new epitope in the acidic region following the A2 domain
Author:
Affiliation:
1. From the Department of Plasma Proteins, CLB, the Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, and the Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/96/2/540/1665830/540.pdf
Reference34 articles.
1. The life cycle of coagulation factor VIII in view of its structure and function.;Lenting;Blood.,1998
2. Hemophilia A.;Hoyer;N Engl J Med.,1994
3. The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies.;Prescott;Blood.,1997
4. Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site.;Scandella;Blood.,1995
5. Residues Glu2181–Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII.;Healey;Blood.,1998
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