Serum Vitamin B12-Binding Capacity and Muramidase Changes With Cyclic Neutropenia Induced by Cytosine Arabinoside-Reference-Cited by-同舟云学术

Serum Vitamin B12-Binding Capacity and Muramidase Changes With Cyclic Neutropenia Induced by Cytosine Arabinoside

Published:1971-01-01 Issue:1 Volume:37 Page:31-39
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

CARMEL RALPH¹²,COLTMAN CHARLES A.¹³

Affiliation:

1. Aerospace Medical Laboratory (Clinical) and the Hematology-Oncology Service, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas.

2. MRC Experimental Hematology Unit, St. Mary's Hospital Medical School, London, England; formerly Research Associate, Aerospace Medical Laboratory (Clinical), Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas.

3. Hematology-Oncology Service, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas.

Abstract

Abstract A patient with acute leukemia in sustained complete remission was studied for 8 months. Periodic maintenance chemotherapy with cytosine arabinoside regularly induced granulocytopenia, with granulocytosis upon marrow recovery. Changes in serum unbound B12-binding capacity (UBBC) occurred simultaneously with peripheral granulocyte fluctuations. Both α- and β-globulin UBBC were affected. Serum muramidase rose and fell out of phase with the granulocyte and UBBC fluctuations, preceding them by several days. These data support the concept that serum UBBC and serum muramidase reflect different aspects of granulocyte activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/37/1/31/575880/31.pdf

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