Possible Thrombosthenin Defect in Glanzmann’s Thrombasthenia-Reference-Cited by-同舟云学术

Possible Thrombosthenin Defect in Glanzmann’s Thrombasthenia

Published:1972-03-01 Issue:3 Volume:39 Page:377-381
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Booyse Francois¹²,Kisieleski Donna¹³,Seeler Ruth¹⁴,Rafelson Max¹²

Affiliation:

1. Department of Biochemistry, Rush Medical College, Rush-Presbyterian-St. Luke’s Medical Center, and Division of Pediatrics, Cook County Children’s Hospital, Chicago, Ill.

2. Rush Medical College, Chicago, Ill.

3. Department of Biochemistry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Ill.

4. Division of Pediatric Hematology, Cook County Children's Hospital, Chicago, Ill.

Abstract

Abstract Microquantitation of thrombosthenin by single radial immunodiffusion in conjunction with a specific immunohistochemical antibody staining technique has indicated an immunologic defect or absence of the surface-localized thrombosthenin (S-thrombosthenin) in platelets from Glanzmann’s thrombasthenic patients. In addition, ADP- and ATP-induced changes of the surface of normal platelets could not be demonstrated with Glanzmann’s thrombasthenic platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/39/3/377/576386/377.pdf

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4. Correction of clot retraction in thrombasthenia by ATP and ristocetin;Thrombosis Research;1978-05

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