Serologic Specificity of Human Anti-IgA and its Significance in Transfusion-Reference-Cited by-同舟云学术

Serologic Specificity of Human Anti-IgA and its Significance in Transfusion

Published:1969-11-01 Issue:5 Volume:34 Page:573-581
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

VYAS G. N.¹²,HOLMDAHL L.¹³,PERKINS H. A.¹⁴,FUDENBERG H. H.¹⁵

Affiliation:

1. Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, and the Irwin Memorial Blood Bank of the San Francisco Medical Society, San Francisco, California.

2. Section of Hematology and Immunology and Division of Clinical Pathology and Laboratory Medicine, Department of Medicine, University of California School of Medicine.

3. Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine.

4. University of California School of Medicine; Director of Research, Irwin Memorial Blood Bank of the San Francisco Medical Society, San Francisco.

5. University of California School of Medicine.

Abstract

Abstract Anti-IgA antibodies detected by a passive hemagglutination assay are either specific for the IgA class or they are of limited specificity. Persons lacking IgA can produce class-specific anti-IgA as a result of parenteral exposure to incompatible IgA globulin in blood and its components. In contrast, persons with normal levels of IgA may produce anti-IgA of limited specificity. Either type of anti-IgA antibodies was present in 86 per cent of anaphylactoid and urticarial transfusion reactions. A majority of these antibodies are of the IgG class.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/34/5/573/575120/573.pdf

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