Humoral and cellular responses after COVID-19 vaccination in anti-CD20-treated lymphoma patients

Author:

Liebers Nora12,Speer Claudius3,Benning Louise3ORCID,Bruch Peter-Martin1ORCID,Kraemer Isabelle1,Meissner Julia1,Schnitzler Paul4,Kräusslich Hans-Georg4,Dreger Peter1,Mueller-Tidow Carsten12ORCID,Poschke Isabel5ORCID,Dietrich Sascha126ORCID

Affiliation:

1. Department of Medicine V, Heidelberg University Hospital, Heidelberg, Germany;

2. National Center for Tumor Diseases Heidelberg, Heidelberg, Germany;

3. Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany;

4. Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany;

5. Immune Monitoring Unit, German Cancer Research Center, Heidelberg, Germany; and

6. European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Abstract

Three reports address the protection of the vulnerable population of patients with hematologic malignancies in the face of the ongoing COVID pandemic. The reports suggest that some patients who fail to mount a B-cell response to vaccine may nevertheless have protective T cell responses. As a group, these reports suggest that patients should continue to be immunized with additional doses to attempt to improve immune response but that they need to maintain the precautions recommended for the unvaccinated.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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