Genotoxic aldehydes in the hematopoietic system-Reference-Cited by-同舟云学术

Genotoxic aldehydes in the hematopoietic system

Published:2022-04-07 Issue:14 Volume:139 Page:2119-2129
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Meng¹²³^ORCID,Dingler Felix A.⁴^ORCID,Patel K. J.⁴

Affiliation:

1. Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom;

2. Department of Haematology and

3. Wellcome-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom; and

4. Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Abstract

Abstract Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem cells and blood production. To protect against aldehydes, mammals have evolved a family of enzymes to detoxify aldehydes, and the Fanconi anemia DNA repair pathway to process aldehyde-induced DNA damage. Loss of either protection mechanisms in humans results in defective hematopoiesis and predisposition to leukemia. This review will focus on the impact of genotoxic aldehydes on hematopoiesis, the sources of endogenous aldehydes, and potential novel protective pathways.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/139/14/2119/1887353/bloodbld2019004316c.pdf

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