Fusion-harboring mast cells can explain molecular positivity in flow cytometric MRD-negative core-binding factor AML

Author:

Cook Jacqueline A.1,Lott Loren1,Perry Jenna1,Eckel Ashley M.1ORCID,Xu Dongbin1ORCID,Hudson Chad A.1,Wells Denise A.1,Loken Michael R.1,Menssen Andrew J.1ORCID

Affiliation:

1. Hematologics Inc, Seattle, WA

Abstract

Abstract Molecular measurable residual disease can persist in core-binding factor acute myeloid leukemia in otherwise disease-free patients. Utilizing cell sorting followed by fluorescent in situ hybridization, we show that detection is due to mast cells.

Publisher

American Society of Hematology

Reference17 articles.

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2. Comprehensive mutation profile in acute myeloid leukemia patients with RUNX1-RUNX1T1 or CBFB-MYH11 fusions;Qin;Turk J Haematol,2022

3. CBFB-MYH11 fusion sequesters RUNX1 in cytoplasm to prevent DNMT3A recruitment to target genes in AML;Liu;Front Cell Dev Biol,2021

4. Core binding factor leukemia: chromatin remodeling moves towards oncogenic transcription;Beghini;Cancers (Basel),2019

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