A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells-Reference-Cited by-同舟云学术

A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

Published:2019-11-28 Issue:22 Volume:134 Page:1960-1972
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Park Chun Shik¹,Lewis Andrew H.¹²,Chen Taylor J.¹²,Bridges Cory S.¹^ORCID,Shen Ye¹²,Suppipat Koramit³,Puppi Monica¹,Tomolonis Julie A.⁴,Pang Paul D.²,Mistretta Toni-Ann¹,Ma Leyuan⁵,Green Michael R.⁵,Rau Rachel⁶^ORCID,Lacorazza H. Daniel¹^ORCID

Affiliation:

1. Department of Pathology and Immunology and

2. Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, Houston, TX;

3. Texas Children’s Cancer and Hematology Center, Texas Children’s Hospital, Houston, TX;

4. MD/PhD Program, Baylor College of Medicine, Houston, TX;

5. Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA;

6. Department of Pediatrics-Oncology, Baylor College of Medicine, Houston, TX

Abstract

Park et al describe a novel KLF4-mediated pathway that promotes chromic myeloid leukemia (CML) stem cell (LSC) survival. Deletion of KLF4 in a mouse model of CML decreases LSC survival through repression of Dyrk2, resulting in c-Myc depletion and increased p53 activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/22/1960/1543152/blood875922.pdf

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