Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion-Reference-Cited by-同舟云学术

Proximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of von Willebrand factor secretion

Published:2019-07-01 Issue:12 Volume:134 Page:979-982
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Holthenrich Anna¹,Drexler Hannes C. A.²^ORCID,Chehab Tarek¹,Naß Johannes¹,Gerke Volker¹

Affiliation:

1. Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany; and

2. Max Planck Institute for Molecular Biomedicine, Münster, Germany

Abstract

Abstract Weibel-Palade (WPB) bodies are endothelial cell organelles that store von Willebrand factor (VWF) and other proteins important for vascular hemostasis. Holthenrich and colleagues used an elegant proximity proteomics approach to compile a complete catalog of WPB-associated proteins and identify Munc13-2 as a novel factor mediating VWF secretion via WPB exocytosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/12/979/1223483/bloodbld2019000786.pdf

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