Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemia

Published:2019-09-05 Issue:10 Volume:134 Page:793-797
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gocho Yoshihiro¹²,Yang Jun J.¹²³^ORCID

Affiliation:

1. Hematological Malignancies Program, Comprehensive Cancer Center,

2. Department of Pharmaceutical Sciences, and

3. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN

Abstract

Abstract Recent genome-wide studies have revealed a plethora of germline variants that significantly influence the susceptibility to acute lymphoblastic leukemia (ALL), thus providing compelling evidence for genetic inheritance of this blood cancer. In particular, hematopoietic transcription factors (eg, ETV6, PAX5, IKZF1) are most frequently implicated in familial ALL, and germline variants in these genes confer strong predisposition (albeit with incomplete penetrance). Studies of germline risk factors for ALL provide unique insights into the molecular etiology of this leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/10/793/1554431/bloodbld2018852400c.pdf

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