Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia

Author:

Lucena-Araujo Antonio R.123ORCID,Coelho-Silva Juan L.123ORCID,Pereira-Martins Diego A.123ORCID,Silveira Douglas R.4ORCID,Koury Luisa C.2,Melo Raul A. M.5ORCID,Bittencourt Rosane6,Pagnano Katia7ORCID,Pasquini Ricardo8,Nunes Elenaide C.8,Fagundes Evandro M.9,Gloria Ana B.9,Kerbauy Fábio10,de Lourdes Chauffaille Maria10,Bendit Israel4ORCID,Rocha Vanderson3411ORCID,Keating Armand12,Tallman Martin S.13,Ribeiro Raul C.14ORCID,Dillon Richard15,Ganser Arnold16,Löwenberg Bob17ORCID,Valk P. J. M.17,Lo-Coco Francesco1819,Sanz Miguel A.2021ORCID,Berliner Nancy22ORCID,Rego Eduardo M.234ORCID

Affiliation:

1. Department of Genetics, Federal University of Pernambuco, Recife, Brazil;

2. Department of Internal Medicine, Medical School of Ribeirao Preto, and

3. Center for Cell Based Therapy, University of Sao Paulo, Ribeirao Preto, Brazil;

4. Hematology Division, Faculdade de Medicina, University of Sao Paulo, Sao Paulo, Brazil;

5. Department of Internal Medicine, University of Pernambuco, Recife, Brazil;

6. Hematology Division, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;

7. Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil;

8. Hematology Division, Federal University of Parana, Curitiba, Brazil;

9. Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil;

10. Department of Hematology, Federal University of Sao Paulo, Sao Paulo, Brazil;

11. Department of Haematology, Churchill Hospital, Oxford University, Oxford, United Kingdom;

12. Princess Margaret Cancer Centre, Toronto, ON, Canada;

13. Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY;

14. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

15. Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom;

16. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;

17. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

18. Department of Biopathology, University Tor Vergata, Rome, Italy;

19. Unit of Neuro-oncohematology, Santa Lucia Foundation, Rome, Italy;

20. Department of Hematology, Valencia University Medical School, Valencia, Spain;

21. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, Madrid, Spain; and

22. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Abstract

Abstract Luceno-Araujo et al use assays of mutations associated with myeloid malignancy to propose an integrative prognostic score for acute promyelocytic leukemia (ISAPL) in patients treated with all-trans retinoic acid and anthracycline-based therapy. They demonstrate that the ISAPL is superior for predicting outcomes and identifying patients who may benefit from alternative therapies to maximize their chance of a cure.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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