Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson’s Disease?-Reference-Cited by-同舟云学术

Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson’s Disease?

Published:2021-07-30 Issue:3 Volume:11 Page:909-917
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Barker Roger A.¹,Björklund Anders²,Frucht Steven J.³,Svendsen Clive N.⁴

Affiliation:

1. Department of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, Forvie Site, Cambridge, UK

2. Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

3. NYU Grossman School of Medicine, New York, USA

4. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Abstract

The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson’s Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. In this debate, we discuss which of these approaches will evolve to be the treatment of choice for Parkinsonian patients in the future.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Clinical Neurology

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Defining the unknowns for cell therapies in Parkinson's disease;Disease Models & Mechanisms;2022-09-27

2. 100 plus years of stem cell research—20 years of ISSCR;Stem Cell Reports;2022-06

3. More than a participant in trials of cell and gene therapy: Hearing the voices of people living with neurodegenerative diseases;International Review of Neurobiology;2022