Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria

Author:

Alikhani Nyosha12,Guo Lan1,Yan Shiqiang1,Du Heng1,Pinho Catarina Moreira2,Chen John Xi3,Glaser Elzbieta2,Yan Shirley ShiDu1456

Affiliation:

1. Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA

2. Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

3. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

4. Department of Pathology and Cell Biology, College of Physicians and Surgeons of Columbia University, New York, NY, USA

5. Department of Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians & Surgeons of Columbia University, New York, NY, USA

6. Department of Pharmacology and Toxicoogy and Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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