Cerebello-Parietal Functional Connectivity in Amnestic Mild Cognitive Impairment-Reference-Cited by-同舟云学术

Cerebello-Parietal Functional Connectivity in Amnestic Mild Cognitive Impairment

Published:2024-07-30 Issue:3 Volume:100 Page:775-782
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Lin Chi-Ying R.¹²,Yonce Shayla S.¹,Pacini Nat J.¹,Yu Melissa M.¹,Bishop Jeffrey S.¹,Pavlik Valory N.¹,Salas Ramiro³⁴⁵⁶

Affiliation:

1. Alzheimer’s Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA

2. Parkinson’s Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX, USA

3. Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA

4. The Menninger Clinic, Baylor College of Medicine, Houston, TX, USA

5. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, USA

6. Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA

Abstract

The role of the cerebellum in amnestic mild cognitive impairment (aMCI), typically a prodromal stage of Alzheimer’s disease, is not fully understood. We studied the lobule-specific cerebello-cerebral connectivity in 15 cognitively normal and 16 aMCI using resting-state functional MRI. Our analysis revealed weaker connectivity between the cognitive cerebellar lobules and parietal lobe in aMCI. However, stronger connectivity was observed in the cognitive cerebellar lobules with certain brain regions, including the precuneus cortex, posterior cingulate gyrus, and caudate nucleus in participants with worse cognition. Leveraging these measurable changes in cerebello-parietal functional networks in aMCI could offer avenues for future therapeutic interventions.

Publisher

IOS Press

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